The Klinikum rechts der Isar university hospital of the Technical University of Munich is a major European center of medical care and education. With over 1.161 beds and almost 5.500 employees, we treat some 300.000 patients per year with state-of-the art care.
We are offering a PhD position as part of a collaboration in Gerhard Rammes’ group at the Department of Anaesthesiology, Klinikum rechts der Isar of the Technischen Universität in Munich. The primary goal of this study is to investigate how enhanced neurosteroidogenesis modulates the function of the most important GABAA receptor subtypes on the synaptic, cellular and network level. By investigating the molecular and cellular mechanisms how neurosteroids reverse detrimental hypoxic effects on long-term potentiation, a cellular correlate for learning and memory, and apoptosis we want to identify synaptic and extrasynaptic GABAA receptors involved in mediating neurosteroid-induced neuroprotection. We combine electrophysiological and optical recordings with genetic tools for GABAA receptor manipulation.
The PhD position is offered for 3 years (2/3 E13) and is part of a mutual DFG-funded project which will be done in collaboration with Prof Bernd Antkowiak at the Department of Anaesthesiology in Tübingen. With this project we intend to elaborate the molecular actions of neurosteroids and their interactions with anaesthetic agents in order to evaluate future applications in clinical anaesthesia. The successful candidate will perform electrophysiological (extracellular and patch-clamp recordings) and optical (voltage-sensitive dye imaging and calcium imaging) monitoring of neuronal activity in hippocampal slices. The project requires a strong interest in neuropharmacology, neurophysiology and the ability to work in a team.
Payment is according to tarif (TV-L).
We give priority to severely disabled applicants with essentially equal qualifications.
Applications will be considered via the GSN application tool and should contain a statement about methodological experience and a CV. Interested candidates are welcome to establish contact via email to g.rammestum.de